Small Cell Lung Cancer Project

Download Small Cell Lung Cancer Project Data Files

Mislabeling of the SW-1271 and NCI-H2066 SCLC lines was discovered after the molecular and drug response measures had been recorded. The correct identity of both cell lines has been confirmed using DNA fingerprinting and analytical tools. The December 2019 release of the SCLC dataset includes corrected labeling of the cell lines.

The December 2019 release provides corrected labeling for these two cell lines in all files for all measures of drug response, transcript expression, miRNA expression. The mislabeling was discovered before the methylation studies; so, all of the DNA methylation datasets have correct designations of the SW-1271 and NCI-H2066 lines.

The previous, uncorrected versions of the downloadable data files are still available here, but are designated as OBSOLETE

Website users who retrieved the March 2015 versions of the data should switch the labels between SW-1271 and NCI-H2066 in their data files, or download the updated files from the December 2019 release.

March 2015 OBSOLETEConcentration/Response Data Download
March 2015 OBSOLETEAffymetrix Exon Microarray Data Download
March 2015 OBSOLETENanoString microRNA Expression Data Download
December 2019 CURRENTConcentration/Response Data Download
December 2019 CURRENTAffymetrix Exon Microarray Data Download
December 2019 CURRENTNanoString microRNA Expression Data Download
December 2019 CURRENTNanoString microRNA Identifier Annotations Download
December 2019 CURRENTFinal dataset of methylation beta-values of 760,637 individual probes in 66 SCLC cell lines after QC filtering of the probes based on detection p values and after removal of the probes overlapping with SNPs. Methylation data were generated using Illumina Infinium MethylationEPIC BeadChip. Download
December 2019 CURRENTMethylation beta-values of 866,091 individual probes in 66 SCLC cell lines after QC filtering of the probes based on detection p values, prior to filtering out the probes that may overlap with SNPs. Download
December 2019 CURRENTMethylation of gene regions in 66 SCLC cell lines, averaged among methylation beta-values of individual probes within each region. NProbesInRegion indicates the number of probes contributing to the methylation value of that region. The file contains data for 108,795 regions belonging to 26,239 genes, transcripts, and miRNA listed in the Infinium MethylationEPIC BeadChip manifest annotation. Download
December 2019 CURRENTExpression of 18,690 transcripts in 67 SCLC cell lines after adjustment for batch effects. Transcript expression was measured using the Affymetrix GeneChip Human Exon 1.0 ST Array. Download
December 2019 CURRENTExpression of 800 miRNA in 67 SCLC cell lines after adjustment for batch effects. miRNA expression was measured using the NanoString platform. Download